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Apoptosis: lessons fromin vitrosystems

Authors
Journal
Trends in Cell Biology
0962-8924
Publisher
Elsevier
Publication Date
Volume
5
Issue
6
Identifiers
DOI: 10.1016/s0962-8924(00)89006-6
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Although apoptosis is a major factor in metazoan morphogenesis and tissue homeostasis, its underlying biochemical mechanisms are poorly understood. This is now beginning to change as cell-free systems for the study of apoptosis start to reveal some of the activities involved. As suggested by earlier genetic analyses, a proteinase with properties resembling those of the interleukin-1-β-converting enzyme (ICE) has been shown to initiate the apoptotic cascade in vitro. Curiously, results obtained with the cell-free systems suggest that essential downstream effectors of the apoptotic response may be intrinsic components of healthy nuclei.

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