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EEG Derived Brain Activity Reflects Treatment Response from Vagus Nerve Stimulation in Patients with Epilepsy.

Authors
  • Wostyn, Simon1, 2
  • Staljanssens, Willeke1, 2
  • De Taeye, Leen3
  • Strobbe, Gregor1
  • Gadeyne, Stefanie3
  • Van Roost, Dirk4
  • Raedt, Robrecht3
  • Vonck, Kristl3
  • van Mierlo, Pieter1, 2, 5
  • 1 * MEDISIP, Department of Electronics and Information Systems, Ghent University, Ghent, Belgium. , (Belgium)
  • 2 † iMinds Medical IT Department, Ghent University, Ghent, Belgium. , (Belgium)
  • 3 ‡ LCEN3, Department of Neurology, Ghent University, Ghent, Belgium. , (Belgium)
  • 4 § Department of Neurosurgery, Ghent University Hospital, Ghent, Belgium. , (Belgium)
  • 5 ¶ Functional Brain Mapping lab, University of Geneva, Geneva, Switzerland. , (Switzerland)
Type
Published Article
Journal
International journal of neural systems
Publication Date
Jun 01, 2017
Volume
27
Issue
4
Pages
1650048–1650048
Identifiers
DOI: 10.1142/S0129065716500489
PMID: 27712133
Source
Medline
Keywords
License
Unknown

Abstract

The mechanism of action of vagus nerve stimulation (VNS) is yet to be elucidated. To that end, the effects of VNS on the brain of epileptic patients were studied. Both when VNS was switched "On" and "Off", the brain activity of responders (R, seizure frequency reduction of over 50%) was compared to the brain activity of nonresponders (NR, seizure frequency reduction of less than 50%). Using EEG recordings, a significant increase in P300 amplitude for R and a significant decrease in P300 amplitude for NR were found. We found biomarkers for checking the efficacy of VNS with accuracy up to 94%. The results show that P300 features recorded in nonmidline electrodes are better P300 biomarkers for VNS efficacy than P300 features recorded in midline electrodes. Using source localization and connectivity analyses, the activity of the limbic system, insula and orbitofrontal cortex was found to be dependent on VNS switched "On" versus "Off" or patient group (R versus NR). The results suggest an important role for these areas in the mechanism of action of VNS, although a larger patient study should be done to confirm the findings.

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