Abstract A multiscale material defect simulation established to evaluate neutron induced damages on metals is applied to an estimation of material degradation in helium cooled molten lithium blankets in which four different spectral shifter materials are examined as a means of maximizing the tritium breeding ratio through proper shaping of the neutron spectrum. The multiscale system consists of a Monte Carlo neutron transport code, a recoil spectrum generation code, a molecular dynamics code, a high energy cascade breakup model, an object kinetic Monte Carlo code, and a simple formula as the shear stress estimator. The average recoil energy of the primary knock-on atoms, the total concentration of the defects, average defect sizes, and the increase in shear stress after a certain irradiation time are calculated for each spectral shifter. Among the four proposed materials of B4C, Be, Graphite and TiC, B4C reveals the best shielding performance in terms of neutron radiation hardening. The result for the increase in shear stress after 100 days of irradiation indicates that the increased shear stress is 1.5GPa for B4C which is about 40% less than that of the worst one, the graphite spectral shifter. The other damage indicators show consistent trends.