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A comparison of masking effects of haloperidol versus molindone in tardive dyskinesia

Authors
Journal
Schizophrenia Research
0920-9964
Publisher
Elsevier
Publication Date
Volume
3
Identifiers
DOI: 10.1016/0920-9964(90)90016-z
Keywords
  • Haloperidol
  • Molindone
  • Neuroleptic
  • Tardive Dyskinesia
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Abstract An experimental method was utilized to compare the masking effects of two neuroleptic agents—molindone and haloperidol—on 18 neuroleptic-treated schizophrenic patients exhibiting operationally defined withdrawal-exacerbated tardive dyskinesia. After a week on one of these two medications at preestablished doses equivalent to that of the pre-study neuroleptic, molindone-masked total AIMS scores by significantly less (12%) than haloperidol (27%). Similarly, during a second week when the dose of these neuroleptics was equivalent to 200% that of the pre-study dose, molindone masked the total AIMS score significantly less (23%) as compared to haloperidol (53%). Several interpretations of this findings are considered. This study demonstrates the feasibility of a method that may offer a model for understanding pharmacological differences among neuroleptic medications.

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