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Erratum to “Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains”

Authors
Journal
Virus Research
0168-1702
Publisher
Elsevier
Publication Date
Volume
79
Identifiers
DOI: 10.1016/s0168-1702(01)00295-7
Keywords
  • Genome Comparison
  • Porcine Reproductive And Respiratory Syndrome Virus (Prrsv)
Disciplines
  • Medicine

Abstract

Abstract Two full-length porcine reproductive and respiratory syndrome virus (PRRSV) genomes, strain VR-2332 and its cell culture passaged descendent RespPRRS vaccine strain, were compared and analyzed in order to identify possible sites of attenuation. Of the 41 nucleotide changes, 12 resulted in conservative changes and 18 produced non-conservative changes. The results suggest that key amino acids in ORF1 may contribute to the phenotype of RespPRRS, which includes increased growth rate on MA-104 cells and decreased virulence in swine. The results provide a genetic basis for future manipulation of a PRRSV reverse genetics system.

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