Abstract Cadmium is expected to be the solvent for pyrochemical processing of the metallic nuclear fuel. Therefore, thermodynamic properties of cadmium with various fuel and clad elements are of interest. Enthalpies of formation of the intermetallic compounds of Cd–Sr system, Cd 0.917Sr 0.083, Cd 0.857Sr 0.143 and Cd 0.667Sr 0.333 were determined by precipitation using Calvet calorimeter. Enthalpies of formation of the compounds were found to be −3.05 ± 0.5 kJ mol −1 at 723 K, −14.2 ± 0.7 kJ mol −1 at 843 K and −28.4 ± 0.8 kJ mol −1 at 863 K, respectively. Enthalpies of formation of Cd 0.917Sr 0.083 and Cd 0.857Sr 0.143 were also determined by partial enthalpy of formation measurements and the values were found to be −3.9 ± 1.1 kJ mol −1 at 723 K and −13.42 ± 1.2 kJ mol −1 at 843 K, respectively. Miedema model was used to estimate the enthalpies of formation of these compounds and the estimated values were compared with the experimentally determined values.