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Hydroxylation of taurolithocholate by isolated human liver microsomes II. Cytochrome P-450 dependency

Authors
Journal
Biochimica et Biophysica Acta (BBA) - General Subjects
0304-4165
Publisher
Elsevier
Publication Date
Volume
354
Issue
2
Identifiers
DOI: 10.1016/0304-4165(74)90002-6

Abstract

Abstract The conversion of taurolithocholate to taurohyodeoxycholate by 6α-hydroxylation by isolated human liver microsomes and NADPH is inhibited by CO and the inhibition is maximally reversedby monochromatic light at 450 nm indicating that the reaction is cytochrome P-450 dependent.

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