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Enantioselective total synthesis of a novel polyketide natural product(+)-integrasone, an HIV-1 integrase inhibitor

Royal Society of Chemistry
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  • Organic Chemistry


Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio-, chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.

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