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Editorial: Cancer plasticity and the microenvironment: Implications for immunity and therapy response

  • Behren, Andreas
  • Thompson, Erik W.
  • Anderson, Robin L.
  • Ferrao, Petranel T.
Publication Date
May 07, 2019
Queensland University of Technology ePrints Archive


Over the last decade, our understanding of how cancer cells interact with their microenvironment has grown exponentially. It has become evident that a complex interplay exists between malignant cells and benign host cells. The cancer cells and the “normal” cells, especially the immune compartment, undergo constant co-evolution to dynamically “shape” each other. Early attempts to utilize immune cells to favor anti-tumor responses date back more than a hundred years, when William Coley used bacteria to evoke immune responses in cancer patients, however, the results were controversial. Now, in the twenty-first century, “evading the immune system” has been recognized as a key hallmark of cancer.

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