Abstract The thermal fatigue resistance of cast single-crystalline CMSX-4 samples featuring an edge composed of a 1-mm-deep layer of laser-deposited epitaxial single-crystalline CMSX-4 is compared with that of samples made entirely of the virgin base material. Tests are conducted by cycling between 200 and 1100°C, and recording the progression of the largest crack growing in each sample. It is found that crack growth rates in samples with laser claddings are around twice those in the base material; this is chiefly attributed to their different thermal history. Resistance to crack initiation was lower in two out of three laser-clad samples than in the base material; this is attributed to interdendritic flaws in laser-clad layers of these two samples. The performance of the third coated sample was comparable with that of the base material.