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Ethynylestradiol and norethindrone metabolism by everted sacs of rat ileum

Authors
Journal
Contraception
0010-7824
Publisher
Elsevier
Publication Date
Volume
18
Issue
2
Identifiers
DOI: 10.1016/0010-7824(78)90088-4
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract The absorption of radioactively labelled norethindrone and ethynylestradiol through the walls of everted sacs of rat ileum has been studied. Norethindrone was metabolised, probably by reduction of the A-ring, but there was little evidence of conjugation. The capacity of the norethindrone metabolising system was high enough to be of pharmacological significance. There was no evidence of metabolism of the steroid nucleus in the case of ethynylestradiol, but there was extensive conjugation as a glucuronide, particularly by middle portions of the ileunu.

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