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Ectopic expression of protein kinase C-β sensitizes head and neck squamous cell carcinoma to diterpene esters.

Authors
Type
Published Article
Journal
Anticancer Research
1791-7530
Publisher
International Institute of Anticancer Research
Publication Date
Volume
35
Issue
3
Pages
1291–1296
Identifiers
PMID: 25750277
Source
Medline
Keywords
License
Unknown

Abstract

Re-expression of PKCβ in head and neck SCC cell lines leads to cells one thousand-times more sensitive to the cytotoxic effects of phorbol or diterpene esters in culture. This highlights the importance of the isoform in tumor progression and presents the potential benefit of these compounds in malignancies expressing the protein, and in combination therapy.

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