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Ecoimmunology in degus: interplay among diet, immune response, and oxidative stress

Authors
  • Ramirez-Otarola, Natalia
  • Sarria, Mauricio
  • Rivera, Daniela S.
  • Sabat, Pablo
  • Bozinovic, Francisco
Type
Published Article
Journal
Journal of Comparative Physiology B
Publisher
Springer Berlin Heidelberg
Publication Date
Nov 28, 2018
Volume
189
Issue
1
Pages
143–152
Identifiers
DOI: 10.1007/s00360-018-1195-9
Source
Springer Nature
Keywords
License
Yellow

Abstract

The relationships between immunity, oxidative stress, and diet have not often been studied together. Despite this, it has been shown that dietary proteins can have effects on the functioning of the immune system and the oxidative status of animals. Here we evaluated the effects of dietary proteins on the response to an antigen and oxidative status of Octodon degus (Rodentia). We acclimated adult individuals to high-protein and low-protein diets and evaluated several aspects of the acute phase response and variables associated with oxidative status. After the immune challenge, animals acclimated to the high-protein diet had more inflammatory proteins and body mass losses than the group acclimated to a low-protein diet. Overall, the immune challenge increased the production of inflammatory proteins, total antioxidant capacity, lipid peroxidation, and duration of rest periods. In contrast, we did not find an interaction between diet and the challenge with the antigen. Overall, our results do not reveal an enhanced response to an antigen nor effects on the oxidative status of degus individuals subjected to a high-protein diet.

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