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Eclipta prostrata Improves DSS-Induced Colitis through Regulation of Inflammatory Response in Intestinal Epithelial Cells.

  • Kim, Dae-Seung1
  • Kim, Sung-Hee1
  • Kee, Ji-Ye1
  • Han, Yo-Han1
  • Park, JinBong2
  • Mun, Jeong-Geon1
  • Joo, Moon-Jung1
  • Jeon, Yong-Deok3
  • Kim, Su-Jin4
  • Park, Sang-Hyun5
  • Park, Sung-Joo6
  • Um, Jae-Young2
  • Hong, Seung-Heon1
  • 1 * Department of Oriental Pharmacy, College of Pharmacy, Wonkwnag University, Iksan, Jeonbuk 54538, Republic of Korea. , (North Korea)
  • 2 † Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul 02453, Republic of Korea. , (North Korea)
  • 3 ‡ Department of Herbal Medicine Resources, Chonbuk National University, Iksan, Jeonbuk 54596, Republic of Korea. , (North Korea)
  • 4 § Department of Cosmeceutical Science, DaeguHanny University, Kyungsan, Kyungbuk 38610, Republic of Korea. , (North Korea)
  • 5 ¶ Isotope Sciences Lab, Korea Atomic Energy Research Institute, 1266 Shinjeong-Dong, Jeongeup, Jeonbuk 56212, Republic of Korea. , (North Korea)
  • 6 ∥ Department of Herbology, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea. , (North Korea)
Published Article
The American journal of Chinese medicine
Publication Date
Jan 01, 2017
DOI: 10.1142/S0192415X17500562
PMID: 28659027


Eclipta prostrata (EP) and its compounds are known to have several pharmacological effects including anti-inflammatory effects. In the present study, we demonstrated that EP improves the dextran sulfate sodium (DSS)-induced colitis symptoms such as body weight loss, colon length shortening and disease activity index. In DSS-induced colitis tissue, EP controls the protein expressions of cyclooxygenase-2 (COX-2) and hypoxia inducible factor-1[Formula: see text] (HIF-1[Formula: see text]). In addition, the release of prostaglandin E2 and vascular endothelial growth factor-A were significantly reduced by EP administration. EP also inhibited COX-2 and HIF-1[Formula: see text] expressions in the tumor necrosis factor-[Formula: see text] stimulated HT-29 cells. These inhibitory effects of EP occurred by reducing the phosphorylation of I[Formula: see text]B and the translocation of the nuclear factor-[Formula: see text]B (NF-[Formula: see text]B). Additionally, we found through HPLC analysis that wedelolactone, which is an inhibitor of NF-[Formula: see text]B transcription, was contained in water extract of EP. These results indicate that EP can improve colitis symptoms through the modulation of immune function in intestinal epithelial cells and suggests that EP has the potential therapeutic effect to intestinal inflammation.

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