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Interaction of propranolol with GABA stimulated diazepam binding to rat brain membranes

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
19
Issue
4
Identifiers
DOI: 10.1016/0306-3623(88)90160-7

Abstract

Abstract 1. 1. In the case of an intraperitoneal propranolol injection to rats (25 mg/kg), there was no modification in benzodiazepine and γ-amino-butyric acid recognition sites since [ 3H]diazepam or [ 3H]-muscimol binding was not affected. 2. 2. There was an increase in GABA stimulated-diazepam binding (100%, statistical risk lower than 1%). 3. 3. This last result suggests that propranolol treatment can stimulate GABA-benzodiazepine receptor coupling.

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