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Correlation between BMI and insulin resistance in type 2 diabetes mellitus patients on pioglitazone treatment

Authors
Publisher
Galle Medical Association
Publication Date
Keywords
  • Medicine
  • Pioglitazone
  • Type 2 Diabetes Mellitus
Disciplines
  • Medicine

Abstract

Journal articles Abstract We investigated the kinetic effect of pioglitazone on changes of body mass index (BMI), body weight (BW), lipids and insulin resistance (IR) in patients with type 2 diabetes mellitus. Materials and method: 24 patients with type 2 diabetes were randomly selected using fasting blood glucose (FBS) > 7 mmol/L (126 mg/dL) in one occasion if the patient is symptomatic, or in two occasions if the patient is asymptomatic. Patients were treated with 15 mg of pioglitazone (PIO) daily and investigated for BW, BMI, FBS, fasting insulin (FI) & triglycerides (TG). IR was calculated by McAuley (McA), HOMA & QUICKI indices at baseline and repeated after 3 months. Results: Mean age was 45.83 1.82 years. There was no significant difference of BMI (23.95 0.82 2 2 kg/m to 24.08 0.85 kg/m ), BW (58.78 2.00 kg to 59.08 2.00 kg) and TG (1.82 0.08 mmol/L to 1.7 0.05 mmol/L) after 3 months (mean SE, p>0.05). There was a significant reduction in FI (37.58 6.09 to 15.37 3.28 mU/L) and IR by McA (4.68 0.25 to 6.18 0.31) with PIO treatment (p<0.001). Reduction of IR by HOMA and QUICKI indices were also significant (17.51 3.36 to 5.41 1.57 and 0.27 0.0 to 0.34 0.01, p>0.001 respectively) after therapy. There was a reduction of TG levels in our participants but it is not statistically significant. No significant correlation was observed between BMI or BW with any of the IR indices before the therapy but significant correlation developed later between BMI with FI (r = 0.4, p>0.05) and McA (r = 0.48, p = 0. 02) after 3 months. The reduction of hepatic insulin sensitivity index (hepatic ISI) was Correlation between BMI and insulin resistance in type 2 diabetes mellitus patients on pioglitazone treatment 1, 3 1 1 1 Lukshmy M Hettihewa , Lalith P Dharmasiri , Chamil D Ariyaratne , Sudheera S Jayasinghe , 2 4 Thilak P Weerarathna , Imendra G Kotapola 1 2 3 Department of

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