Affordable Access

Publisher Website

HIV-2 Integrase Variation in Integrase Inhibitor-Naïve Adults in Senegal, West Africa

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
6
Issue
7
Identifiers
DOI: 10.1371/journal.pone.0022204
Keywords
  • Research Article
  • Biology
  • Microbiology
  • Virology
  • Viral Classification
  • Retroviruses
  • Medicine
  • Infectious Diseases
  • Sexually Transmitted Diseases
  • Aids
  • Viral Diseases
  • Hiv
  • Hiv Diagnosis And Management
  • Retrovirology And Hiv Immunopathogenesis
Disciplines
  • Biology
  • Medicine

Abstract

Background Antiretroviral therapy for HIV-2 infection is hampered by intrinsic resistance to many of the drugs used to treat HIV-1. Limited studies suggest that the integrase inhibitors (INIs) raltegravir and elvitegravir have potent activity against HIV-2 in culture and in infected patients. There is a paucity of data on genotypic variation in HIV-2 integrase that might confer intrinsic or transmitted INI resistance. Methods We PCR amplified and analyzed 122 HIV-2 integrase consensus sequences from 39 HIV-2–infected, INI-naive adults in Senegal, West Africa. We assessed genetic variation and canonical mutations known to confer INI-resistance in HIV-1. Results No amino acid-altering mutations were detected at sites known to be pivotal for INI resistance in HIV-1 (integrase positions 143, 148 and 155). Polymorphisms at several other HIV-1 INI resistance-associated sites were detected at positions 72, 95, 125, 154, 165, 201, 203, and 263 of the HIV-2 integrase protein. Conclusion Emerging genotypic and phenotypic data suggest that HIV-2 is susceptible to the new class of HIV integrase inhibitors. We hypothesize that intrinsic HIV-2 integrase variation at “secondary” HIV-1 INI-resistance sites may affect the genetic barrier to HIV-2 INI resistance. Further studies will be needed to assess INI efficacy as part of combination antiretroviral therapy in HIV-2–infected patients.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Molecular epidemiology of dual HIV-1/HIV-2 seropos...

on AIDS Research and Human Retrov... July 2003

The use of HIV-1 integrase inhibitors in antiretro...

on Current opinion in HIV and AID... September 2012

HIV-1 proteases from drug-naive West African patie...

on Clinical Infectious Diseases Jul 15, 2005

Viral dynamics of primary HIV-1 infection in Seneg...

on The Journal of Infectious Dise... May 01, 2005
More articles like this..