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Introduction of photocrosslinkable chitosan to polyethylene film by radiation grafting and its blood compatibility

Authors
Journal
Materials Science and Engineering C
0928-4931
Publisher
Elsevier
Publication Date
Volume
24
Issue
4
Identifiers
DOI: 10.1016/j.msec.2003.09.168
Keywords
  • Surface Modification
  • Radiation Grafting
  • O-Butyrylchitosan
  • Polyethylene
  • Blood Compatibility
  • Platelet Adhesion
  • Protein Adsorption
Disciplines
  • Biology
  • Chemistry
  • Medicine
  • Physics

Abstract

Abstract This paper describes research to improve the blood compatibility of polyethylene (PE) film. O-Butyrylchitosan (OBCS) was grafted to PE film by using a radiation grafting technique. The grafted sample films were verified by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA) and the water contact angle measurements. The blood compatibility of the OBCS-grafted PE films was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments that the results were described. The blood compatibility of OBCS-grafted PE film is better than that of blank PE film. These results suggest that the photocrosslinkable chitosan developed here has the potential of serving in blood-contacting applications in medical use.

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