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Topological difference in the three-dimensional sinusoid structure between normal human liver and hepatocellular carcinoma

Authors
Journal
Microvascular Research
0026-2862
Publisher
Elsevier
Publication Date
Volume
42
Issue
3
Identifiers
DOI: 10.1016/0026-2862(91)90062-g
Disciplines
  • Computer Science
  • Mathematics

Abstract

Abstract A quantitative topological analysis of the three-dimensional sinusoid structure of normal human livers and well-differentiated hepatocellular carcinomas was performed with the aid of a computer system for reconstruction from serial tissue sections. The mean cycle rank (number of independent cycles) of the sinusoid network in a given volume tissue, 200 × 200 × 40 μm 3 in size, was 60.6 ± 8.8 in the normal liver and 20.8 ± 11.9 in the hepatocellular carcinoma. Statistically, there was a significant difference between the two values ( P < 0.001), while there was no significant difference in the sinusoid volume of the same size tissue between the normal liver and hepatocellular carcinoma. It was therefore found that the sinusoid network of the hepatocellular carcinoma was more sparsely and coarsely connected in three-dimensional space than that of the normal liver.

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