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Importance of lipid metabolism for intracellular and mitochondrial membrane fusion/fission processes

Authors
Journal
The International Journal of Biochemistry & Cell Biology
1357-2725
Publisher
Elsevier
Publication Date
Volume
41
Issue
10
Identifiers
DOI: 10.1016/j.biocel.2009.02.005
Keywords
  • Mitochondria Dynamics
  • Membrane Fusion
  • Membrane Fission
  • Lipid Metabolism

Abstract

Abstract Mitochondria move along cytoskeletal tracks, fuse and divide. These dynamic features have been shown to be critical for several mitochondrial functions in cell viability and cell death. After a rapid recall of the proteic machineries that are known to be involved, the review will focus on lipids, other key molecular actors of membrane dynamics. A summary of the current knowledge on lipids and their implication in various cellular membrane fusion/fission processes will be first presented. The review will then report what has been discovered or can be expected on the role of the different families of lipids in mitochondrial membrane fusion and fission processes.

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