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Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives

Authors
Publisher
Multidisciplinary Digital Publishing Institute
Publication Date
Keywords
  • Thieno[2
  • 3-<I>B</I>]Thiophene
  • Nucleophilic Addition
  • Hydrazonoyl Halides
  • <I>Bis</I>-Pyrazole
  • Antimicrobial Activity

Abstract

A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin B against Syncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G against Staphylococcus aureus. Moreover, it was more potent than the standard drug streptomycin against Pseudomonas aeruginosa and Escherichia coli.

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