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Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

Authors
  • Belarbi, Karim1
  • Schindowski, Katharina
  • Burnouf, Sylvie
  • Caillierez, Raphaëlle
  • Grosjean, Marie-Eve
  • Demeyer, Dominique
  • Hamdane, Malika
  • Sergeant, Nicolas
  • Blum, David
  • Buée, Luc
Type
Published Article
Journal
Current Alzheimer research
Publication Date
Apr 01, 2009
Volume
6
Issue
2
Pages
152–157
Identifiers
PMID: 19355850
Source
Medline
Language
English
License
Unknown

Abstract

Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the present study, we aimed to further investigate Tau aggregation in cholinergic systems, in a Tau transgenic mouse model. THY-Tau22 mice have recently been described as a novel model of Alzheimer-like Tau pathology without motor deficits. This strain presents an age-dependent development of Tau pathology leading to synaptic dysfunctions as well as learning and memory impairments. In the present work, we observed that Tau pathology differentially affects cerebral structures. Interestingly, early Tau pathology was observed in both hippocampus and basal forebrain. Moreover, some morphological as well as functional alterations of the septohippocampal pathway suggest a disconnection between these two key brain regions in Alzheimer's disease. Finally, these data suggest that Tau pathology may participate in cholinergic degeneration.

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