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The early second hit in trauma management augments the proinflammatory immune response to multiple injuries.

Authors
  • Tschoeke, Sven K1
  • Hellmuth, Markus
  • Hostmann, Arwed
  • Ertel, Wolfgang
  • Oberholzer, Andreas
  • 1 Department of Trauma and Reconstructive Surgery, Charité-University Hospitals Berlin, Campus Benjamin Franklin, Berlin, Germany. [email protected] , (Germany)
Type
Published Article
Journal
The Journal of trauma
Publication Date
Jun 01, 2007
Volume
62
Issue
6
Identifiers
PMID: 17563655
Source
Medline
License
Unknown

Abstract

Immediate surgical treatment of patients with multiple injuries augments the proinflammatory immune response in the early phase of recovery as determined by increased IL-6 and sTREM-1 plasma levels. If not required solely for damage control, the early second hit from additional surgical stress might promote posttraumatic complications by surcharging the innate immune response to injury.

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