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The early second hit in trauma management augments the proinflammatory immune response to multiple injuries.

Authors
Type
Published Article
Journal
The Journal of Trauma: Injury, Infection, and Critical Care
0022-5282
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publication Date
Volume
62
Issue
6
Identifiers
PMID: 17563655
Source
Medline

Abstract

Immediate surgical treatment of patients with multiple injuries augments the proinflammatory immune response in the early phase of recovery as determined by increased IL-6 and sTREM-1 plasma levels. If not required solely for damage control, the early second hit from additional surgical stress might promote posttraumatic complications by surcharging the innate immune response to injury.

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