Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Early reduction in tumour [18F]fluorothymidine (FLT) uptake in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy alone.

Authors
  • Trigonis, Ioannis
  • Koh, Pek Keng
  • Taylor, Ben
  • Tamal, Mahbubunnabi
  • Ryder, David
  • Earl, Mark
  • Anton-Rodriguez, Jose
  • Haslett, Kate
  • Young, Helen
  • Faivre-Finn, Corinne
  • Blackhall, Fiona
  • Jackson, Alan
  • Asselin, Marie-Claude
Type
Published Article
Journal
European Journal of Nuclear Medicine
Publisher
Springer-Verlag
Publication Date
Apr 01, 2014
Volume
41
Issue
4
Pages
682–693
Identifiers
DOI: 10.1007/s00259-013-2632-3
PMID: 24504503
Source
Medline
License
Unknown

Abstract

Across this group of NSCLC patients, RT induced an early, significant decrease in lesion FLT uptake exceeding test-retest variability. This effect is variable between patients, appears distinct between primary and metastatic nodal lesions, and in primary tumours is lower than previously reported for concurrent chemo-RT at a similar time point. These results confirm the potential for FLT PET to report early on radiation response and to enhance the clinical development of novel drug-radiation combinations by providing an interpretable, early pharmacodynamic end point.

Report this publication

Statistics

Seen <100 times