Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Early reduction in tumour [18F]fluorothymidine (FLT) uptake in patients with non-small cell lung cancer (NSCLC) treated with radiotherapy alone.

Authors
Type
Published Article
Journal
European Journal of Nuclear Medicine
1619-7089
Publisher
Springer-Verlag
Publication Date
Volume
41
Issue
4
Pages
682–693
Identifiers
DOI: 10.1007/s00259-013-2632-3
PMID: 24504503
Source
Medline
License
Unknown

Abstract

Across this group of NSCLC patients, RT induced an early, significant decrease in lesion FLT uptake exceeding test-retest variability. This effect is variable between patients, appears distinct between primary and metastatic nodal lesions, and in primary tumours is lower than previously reported for concurrent chemo-RT at a similar time point. These results confirm the potential for FLT PET to report early on radiation response and to enhance the clinical development of novel drug-radiation combinations by providing an interpretable, early pharmacodynamic end point.

Statistics

Seen <100 times