Affordable Access

Early pregnancy loss, premature and low birth weight delivery, and increased maternal lymphocyte cytotoxicity.

Authors
  • Varga, P J
  • Szereday, Z
  • Artner, A
  • Szekeres-Bartho, J
Type
Published Article
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
Publication Date
Apr 01, 1989
Volume
19
Issue
4
Pages
136–140
Identifiers
PMID: 2765140
Source
Medline
License
Unknown

Abstract

Lymphocytes of 628 pregnant women were tested for natural cytotoxic activity to human embryonic fibroblast cells. The data were analyzed with regard to previous obstetric history, symptoms occurring during the present gestation, and the outcome of pregnancy. The normal rate of cytotoxicity during pregnancy was established by determining cytotoxic activity of the lymphocytes from 56 healthy pregnant women. The values higher than the mean + 2 SD of the "normal" (greater than or equal to 40%) were considered as high. Increased cytotoxicity was associated with the occurrence of previous spontaneous and missed abortions, as well as with bleeding and uterine contractions during the present pregnancy observed at the time of the test. In 15 out of 35 cases resulting in spontaneous abortion and 15 out of the 34 pregnancies resulting in missed abortion, cytotoxic activity of the lymphocytes during pregnancy was higher than normal. Similarly, in 38 and 32.7% of the pregnancies resulting in preterm (n = 121) or low birth-weight deliveries (n = 101) respectively, we found increased lymphocyte cytotoxicity, in contrast to that being found in 5.4% of uncomplicated normal pregnancies. These data suggest that at least some pregnancy failures might be immunologically mediated.

Report this publication

Statistics

Seen <100 times