Affordable Access

Access to the full text

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Authors
  • Utzschneider, Daniel T.1
  • Gabriel, Sarah S.1
  • Chisanga, David2, 3, 1, 4
  • Gloury, Renee1
  • Gubser, Patrick M.1
  • Vasanthakumar, Ajithkumar1, 3
  • Shi, Wei2, 3, 4, 1
  • Kallies, Axel1, 3
  • 1 University of Melbourne, Melbourne, Australia , Melbourne (Australia)
  • 2 Olivia Newton-John Cancer Research Institute, Heidelberg, Australia , Heidelberg (Australia)
  • 3 The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia , Melbourne (Australia)
  • 4 La Trobe University, Heidelberg, Victoria, Australia , Heidelberg (Australia)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 24, 2020
Volume
21
Issue
10
Pages
1256–1266
Identifiers
DOI: 10.1038/s41590-020-0760-z
Source
Springer Nature
License
Yellow

Abstract

The developmental timing for exhaustion is still obscure. Kallies and colleagues demonstrate that CD8+ T cell ‘exhaustion’ actually begins in the less-differentiated TCF1+ ‘precursor’ T cell pool during chronic viral infections.

Report this publication

Statistics

Seen <100 times