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The early phase of insulin release in man--a new method for quantitative analysis.

Authors
  • Dörfler, H
  • Wolfram, G
  • Zöllner, N
Type
Published Article
Journal
Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
Publication Date
Dec 15, 1977
Volume
171
Issue
3
Pages
229–241
Identifiers
PMID: 145645
Source
Medline
License
Unknown

Abstract

A method is presented for the quantitative analysis of early insulin release in man. There were measured arterial insulin levels after glibornuride administered intravenously. The mathematical procedure has been modified: Modification I is based on the assumption that early insulin release represents a wave like insulin delivery, modification II is based on the assumption that this insulin bolus is immediately followed by a slower insulin release which must be distinguished from the second phase of insulin release. For the calculations there was used a "primary insulin space" derived from experiments with exogenous insulin. The results of calculations were varying up to 1.5 units of early insulin release in healthy volunteers receiving glibornuride with dosages varying up to 50 mg. The value of the presented method for examinations of insulin release for theoretical and clinical purposes is discussed.

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