Affordable Access

deepdyve-link
Publisher Website

Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity.

Authors
  • De Marco Garcia, Natalia V1
  • Jessell, Thomas M
  • 1 Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA.
Type
Published Article
Journal
Neuron
Publisher
Elsevier
Publication Date
Jan 24, 2008
Volume
57
Issue
2
Pages
217–231
Identifiers
DOI: 10.1016/j.neuron.2007.11.033
PMID: 18215620
Source
Medline
License
Unknown

Abstract

The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by motor pools soon after motor neurons leave the cell cycle, before the formation of muscle nerve side branches in the limb. Using mouse genetics, we show that the status of Nkx6.1 expression in certain motor neuron pools regulates muscle nerve formation, and the pattern of innervation of individual muscles. Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity.

Report this publication

Statistics

Seen <100 times