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The early host and material response of bone-bonding and non-bonding glass-ceramic implants as revealed by scanning electron microscopy and histochemistry.

Authors
  • Müller-Mai, C1
  • Voigt, C
  • Knarse, W
  • Sela, J
  • Gross, U M
  • 1 Institute of Pathology, Steglitz University Clinic, Free University of Berlin, Germany. , (Germany)
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Nov 01, 1991
Volume
12
Issue
9
Pages
865–871
Identifiers
PMID: 1764559
Source
Medline
Language
English
License
Unknown

Abstract

The interface of bone-bonding and non-bonding glass-ceramics in the femur of of rats with the concomitant material and host response has been investigated by scanning electron microscopy (SEM) and histochemistry after transverse fractures in the interface level. During wound healing around these implants, four overlapping phases could be distinguished: (1) blood clot formation, (2) formation of organization tissue, (3) formation of primary bone and calcification, and (4) remodelling which lasts from months to years. This sequence of healing was disturbed around metal ions containing non-bonding implants, as shown by a longer settlement of acid phosphatase positive macrophages and a disturbed calcification at the surface of the material. Only bone-bonding implants developed considerable changes in surface morphology due to leaching and corrosion phenomena. A preferential leaching of the glass moiety, starting at the phase transition between glass and ceramic, contributes to the production of surface elevations which provide adhesion points for fibres and fibrils. Subsequent mineralization of inserting fibres contributes to a tensile strength at the interface. These findings are essential for further understanding of bone-bonding mechanisms and for further development of surface-reactive materials.

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