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Early growth response-1 worsens ventilator-induced lung injury by up-regulating prostanoid synthesis.

Authors
  • Ngiam, Nicola
  • Peltekova, Vanya
  • Engelberts, Doreen
  • Otulakowski, Gail
  • Post, Martin
  • Kavanagh, Brian P
Type
Published Article
Journal
American Journal of Respiratory and Critical Care Medicine
Publisher
American Thoracic Society
Publication Date
May 01, 2010
Volume
181
Issue
9
Pages
947–956
Identifiers
DOI: 10.1164/rccm.200908-1297OC
PMID: 20110555
Source
Medline
License
Unknown

Abstract

This is the first demonstration of a mechanism whereby expression of a novel gene (Egr1) can contribute to VILI via a prostanoid-mediated pathway.

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