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Early evolutionary history (from bacteria to hemichordata) of the omnipresent purinergic signalling: A tribute to Geoff Burnstock inquisitive mind.

Authors
  • Verkhratsky, Alexei1
  • 1 Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, United Kingdom; Achucarro Center for Neuroscience, IKERBASQUE, 48011 Bilbao, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Biochemical pharmacology
Publisher
New York, NY : Elsevier Science Inc
Publication Date
May 01, 2021
Volume
187
Pages
114261–114261
Identifiers
DOI: 10.1016/j.bcp.2020.114261
PMID: 33011161
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Purines and pyrimidines are indispensable molecules of life; they are fundamental for genetic code and bioenergetics. From the very early evolution of life purines have acquired the meaning of damage-associated extracellular signaller and purinergic receptors emerged in unicellular organisms. Ancestral purinoceptors are P2X-like ionotropic ligand-gated cationic channels showing 20-40% of homology with vertebrate P2X receptors; genes encoding ancestral P2X receptors have been detected in Protozoa, Algae, Fungi and Sponges; they are also present in some invertebrates, but are absent from the genome of insects, nematodes, and higher plants. Plants nevertheless evolved a sophisticated and widespread purinergic signalling system relying on the idiosyncratic purinoceptor P2K1/DORN1 linked to intracellular Ca2+ signalling. The advance of metabotropic purinoceptors starts later in evolution with adenosine receptors preceding the emergence of P2Y nucleotide and P0 adenine receptors. In vertebrates and mammals the purinergic signalling system reaches the summit and operates throughout all tissues and systems without anatomical or functional segregation. Copyright © 2020 Elsevier Inc. All rights reserved.

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