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Early CNS neurodegeneration in radiologically isolated syndrome.

Authors
  • Azevedo, Christina J
  • Overton, Eve
  • Khadka, Sankalpa
  • Buckley, Jessica
  • Liu, Shuang
  • Sampat, Mehul
  • Kantarci, Orhun
  • Lebrun Frenay, Christine
  • Siva, Aksel
  • Okuda, Darin T
  • Pelletier, Daniel
Type
Published Article
Journal
Neurology Neuroimmunology & Neuroinflammation
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Jun 01, 2015
Volume
2
Issue
3
Identifiers
DOI: 10.1212/NXI.0000000000000102
PMID: 25884012
Source
Medline
License
Unknown

Abstract

Our data provide novel evidence of thalamic atrophy in RIS and are consistent with previous reports in early MS stages. Thalamic volume loss is present early in CNS demyelinating disease and should be further investigated as a metric associated with neurodegeneration.

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