Affordable Access

deepdyve-link
Publisher Website

Early Childhood Shigellosis and Attention Deficit Hyperactivity Disorder: A Population-Based Cohort Study with a Prolonged Follow-up.

Authors
  • Merzon, Eugene1, 2
  • Gutbir, Yuval3, 4
  • Vinker, Shlomo1, 2
  • Golan Cohen, Avivit1, 2
  • Horwitz, Dana3, 5
  • Ashkenazi, Shai6
  • Sadaka, Yair3, 5
  • 1 Leumit HMO, Tel-Aviv, Israel. , (Israel)
  • 2 Tel Aviv University, Tel Aviv, Israel. , (Israel)
  • 3 Ben-Gurion University of the Negev, Beer-Sheva, Israel. , (Israel)
  • 4 Hadassah Ein Karem Hospital, Jerusalem, Israel. , (Israel)
  • 5 Mental Health Institute, Beer Sheva, Israel. , (Israel)
  • 6 Ariel University, Ariel, Israel. , (Israel)
Type
Published Article
Journal
Journal of Attention Disorders
Publisher
SAGE Publications
Publication Date
Nov 01, 2021
Volume
25
Issue
13
Pages
1791–1800
Identifiers
DOI: 10.1177/1087054720940392
PMID: 32698643
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although the short-term neurological complications of Shigella spp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD. This is a retrospective population-based cohort. Using a large Health Maintenance Organization database, the prevalence of ADHD was investigated among children aged 5-18 years who underwent stool culture prior to the age of 3 years. Of 52,761 children with a stool culture examined, 5,269 (9.98%) had Shigella-positive results. The rate of ADHD was 10.6% and 8.6% among children with Shigella-positive and Shigella-negative stool cultures, respectively (p < .001). Adjusted odds ratio for ADHD after controlling for gender and socioeconomic status was 1.21 (CI 1.13-1.29, p < .001). The younger the child was during Shigella gastroenteritis, the higher was the association with ADHD (p < .001). Early childhood shigellosis is associated with an increased rate of long-term ADHD.

Report this publication

Statistics

Seen <100 times