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Early change in proteinuria as a surrogate end point for kidney disease progression: an individual patient meta-analysis.

Authors
  • Inker, Lesley A1
  • Levey, Andrew S2
  • Pandya, Kruti2
  • Stoycheff, Nicholas2
  • Okparavero, Aghogho2
  • Greene, Tom3
  • 1 Division of Nephrology, Tufts Medical Center, Boston, MA. Electronic address: [email protected]
  • 2 Division of Nephrology, Tufts Medical Center, Boston, MA.
  • 3 Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT.
Type
Published Article
Journal
American Journal of Kidney Diseases
Publisher
Elsevier
Publication Date
Jul 01, 2014
Volume
64
Issue
1
Pages
74–85
Identifiers
DOI: 10.1053/j.ajkd.2014.02.020
PMID: 24787763
Source
Medline
Keywords
License
Unknown

Abstract

These results provide new evidence supporting the use of an early reduction in proteinuria as a surrogate end point, but do not provide sufficient evidence to establish its validity in all settings.

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