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[An early carcinoma of the gallbladder with atypical epithelium ( a report of a case with elevated p53 expression)].

Authors
Type
Published Article
Journal
Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
Publication Date
Volume
14
Issue
1
Pages
65–68
Identifiers
PMID: 8018902
Source
Medline
License
Unknown

Abstract

The p53 tumor suppressor gene is believed to play an important role in the progression of malignant tumors through mutation and overexpression. The p53 protein and Ki-67 immmunochemistry were performed on an early gallbladder carcinoma with atypical epithelium. Overexpression of the protein was found in adenocarcinoma area with diffusely distributed positive cells (p53 index: 76 +/- 24%) and in atypical epithelial areas with foci of diffusely distributed positive cells (p53 Index: 30 +/- 14%), while the Ki-67 index was 6 +/- 4% in the adenocarcinoma areas and 6 +/- 2% in the atypical epithelial areas in each p53 measured corresponding areas. This suggest that p53 protein overexpression occurs in early carcinoma and/or atypical epithelium at least in some cases and that it is an early event in the development of gallbladder adenocarcinomas and also that the atypical epithelium may belong to carcinoma.

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