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Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress.

Authors
  • Antonelli, Marta C1
  • Frasch, Martin G2
  • Rumi, Mercedes3
  • Sharma, Ritika4
  • Zimmermann, Peter5
  • Molinet, Maria S5
  • Lobmaier, Silvia M5
  • 1 Instituto de Biología Celular y Neurociencia "Prof. E. De Robertis", Facultad de Medicina, UBA, Buenos Aires,Argentina | Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Germany. , (Argentina)
  • 2 Department of Obstetrics and Gynecology, University of Washington, Seattle, WA,United States. , (United States)
  • 3 Instituto de Biología Celular y Neurociencia "Prof. E. De Robertis", Facultad de Medicina, UBA, Buenos Aires,Argentina. , (Argentina)
  • 4 Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich,Germany | Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany. , (Germany)
  • 5 Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich,Germany. , (Germany)
Type
Published Article
Journal
Current neuropharmacology
Publication Date
Jan 01, 2022
Volume
20
Issue
1
Pages
94–106
Identifiers
DOI: 10.2174/1570159X19666210125150955
PMID: 33550974
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Functional development of affective and reward circuits, cognition and response inhibition later in life exhibits vulnerability periods during gestation and early childhood. Extensive evidence supports the model that exposure to stressors in the gestational period and early postnatal life increases an individual's susceptibility to future impairments of functional development. Recent versions of this model integrate epigenetic mechanisms of the developmental response. Their understanding will guide the future treatment of the associated neuropsychiatric disorders. A combination of non-invasively obtainable physiological signals and epigenetic biomarkers related to the principal systems of the stress response, the Hypothalamic-Pituitary axis (HPA) and the Autonomic Nervous System (ANS), are emerging as the key predictors of neurodevelopmental outcomes. Such electrophysiological and epigenetic biomarkers can prove to timely identify children benefiting most from early intervention programs. Such programs should ameliorate future disorders in otherwise healthy children. The recently developed Early Family-Centered Intervention Programs aim to influence the care and stimuli provided daily by the family and improving parent/child attachment, a key element for healthy socio-emotional adult life. Although frequently underestimated, such biomarker-guided early intervention strategy represents a crucial first step in the prevention of future neuropsychiatric problems and in reducing their personal and societal impact. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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