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Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt

Bangladesh Pharmacological Society
Publication Date
  • Chemistry
  • Pharmacology
  • Pharmacy
  • Colon Cancer
  • Cytotoxicity
  • Endophytic Fungus
  • Medicine


Endophytic microorganisms are fungi or bacteria that live inside the healthy tissues of the host plants causing no apparent symptoms of diseases. Five endophytic fungal strains labeled as IR-1, IR-2, IR-4, IR-6 and IR-7 (identified as Penicillium thiomii) were isolated from the medicinal plant of Terminalia chebula Retz by culture and sub-culture. The ethyl acetate extract of fungal strains, IR-4, IR-6 and IR-7 inhibited the growth of CaCo-2 colon cancer cell lines in MTT assay with IC50 values of 55, 44 and 67 µg/mL, respectively.DOI:

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