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Taxol Photoaffinity Label: 7-(p-Azidobenzoyl)taxol Synthesis and Biological Evaluation

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
2
Issue
7
Identifiers
DOI: 10.1016/s0960-894x(00)80402-3
Keywords
  • Taxol
  • Synthesis
  • β-Lactams
  • Microtubule Assembly
  • Photoaffinity Label.
Disciplines
  • Biology

Abstract

Abstract An efficient semi-synthetic approach utilizing the appropriately functionalized (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone ( 4) and 7-(p-azidobenzoyl)baccatin III ( 3) is described which leads to the targeted biologically active taxol photoaffinity label 6.

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