Affordable Access

Publisher Website

Intrathecal interferon-γ facilitates the spinal nociceptive flexor reflex in the rat

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
182
Issue
2
Identifiers
DOI: 10.1016/0304-3940(94)90812-5
Keywords
  • Interferon
  • Nitric Oxide
  • Cytokine
  • Pain
  • Hyperalgesia
Disciplines
  • Medicine

Abstract

Abstract The effect of intrathecal (i.t.) injection of the cytokine interferon-γ (IFN-γ) on the spinal nociceptive flexor reflex was examined in decerebrate, spinalized, unanesthetized rats. IFN-γ elicited an initial intense, brief facilitation of the flexor reflex followed by a sustained reflex facilitation lasting 40 ± 5 min (range 20–65 min). The initial and prolonged reflex facilitations by IFN-γ were partially and totally blocked, respectively, by i.t. pretreatment with nitro- l-arginine-ester, an inhibitor of nitric oxide synthase, at doses which did not influence spinal cord blood flow. Spinal application of IFN-γ produced powerful and prolonged facilitation of the flexor reflex, possibly reflecting a hyperalgesic action of this cytokine. The facilitatory effect of IFN-γ was mediated, at least in part, by the activation of the l-arginine-nitric oxide pathway. Thus, IFN-γ released in the CNS may participate in eliciting pain and hyperalgesia in infectious or neuroinflammatory diseases where there is increased production of this cytokine.

There are no comments yet on this publication. Be the first to share your thoughts.