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Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Mechanisms Of Action: Physiological Effects
Disciplines
  • Design

Abstract

Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram-positive and gram-negative bacteria but also broadened the antimicrobial spectrum.

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