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Short-chain acylcarnitines of human blood and urine

Authors
Journal
Biochemical Medicine
0006-2944
Publisher
Elsevier
Publication Date
Volume
28
Issue
2
Identifiers
DOI: 10.1016/0006-2944(82)90070-9

Abstract

Abstract The total carnitine and short-chain acylcarnitines of human blood and urine of healthy adults were identified and quantitated. The major short-chain acylcarnitine of both blood and urine is acetylcarnitine. Urine contains proportionately lower amounts of acetylcarnitine than blood; it has a higher ratio of short-chain acylcarnitine to free carnitine than blood and it contains larger amounts of the branched-chain acylcarnitines, isobutyrylcarnitine, and isovalerylcarnitine than blood. The data indicate that carnitine and possibly acetylcarnitine are preferentially reabsorbed by kidney while isobutyrylcarnitine and isovalerylcarnitine are less readily reabsorbed.

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