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Parenteral clomipramine challenge in depressed adolescents: mood and neuroendocrine response

Authors
Journal
Biological Psychiatry
0006-3223
Publisher
Elsevier
Publication Date
Volume
44
Issue
7
Identifiers
DOI: 10.1016/s0006-3223(97)00447-2
Keywords
  • Clomipramine
  • Intravenous
  • Adolescent
  • Depression
Disciplines
  • Medicine

Abstract

Abstract Background: Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. Methods: Thirteen drug-free outpatient adolescents who met DSM-III-R criteria for MDD were compared to adolescent controls by acute neuroendocrine and mood response to 12.5 mg of parenteral CMI. Results: Repeated measures analysis revealed significant changes from baseline for sadness ( p < .01) between groups, with normal controls increasing sadness rating after CMI. Prolactin (PRL) maximum change score from baseline was decreased in MDD relative to controls ( p < .05). Gender effects on PRL were evident in controls but not in MDD. Conclusions: The findings of PRL blunting in adolescent MDD mirrors previous work in adults. A unique finding is the induction of sadness in normal adolescent controls after CMI infusion.

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