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Chlorinated Aromatic Hydrocarbon Induced Modifications of the Hepatic Endoplasmic Reticulum: Concentric Membrane Arrays*

Authors
Journal
Environmental Health Perspectives
0091-6765
Publisher
Environmental Health Perspectives
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Keywords
  • Articles
Disciplines
  • Agricultural Science
  • Biology
  • Chemistry
  • Medicine

Abstract

Environmental Health Perspectives Chlorinated Aromatic Hydrocarbon Induced Modifications of the Hepatic Endoplasmic Reticulum: Concentric Membrane Arrays* by D. H. Norback and J. R. Allent A number of commercial compounds having chlorinated aromatic hydrocarbon structures are used extensively for medical(3), industrial(4) and agricultural(5) purposes. Quantities of certain parent chlorinated aromatic hydrocarbons and metabolites have been repeatedly detected as residues in the food supply and tissues of birds, fish, and mammals(6-9) including man(10). Chlor- inated diphenyl-p-dioxins have been identified as contaminants of many commercial products, such as certain edible fats, herbicides and disinfectants. > It is suggested that the compound results from the conjugation of commercial chlorinated phenols(1l). Polychlorinated polyphenyls are among the most abundant chlorinated hydrocarbon global pollu- tants. Their contamination of the environment is a result of the widespread commercial use of these compounds for their properties of insulation, adhesiveness, thermoplasticity, chemical inertness, and insolubility. Following this investigation of sequential bio- chemical and ultrastructural alterations within the liver produced by three chlorinated aromatic hydrocarbons - chlorinated diphenyl-p-dioxin, polychlorinated biphenyls (PCBs), and a highly chlorinated triphenyl (PCT)-certain similarities of biochemical and ultrastructural effects of the compounds were observed. The livers of rats fed the chlorinated aromatic hydrocarbons consis- tently contained numerous multi-layered concen- tric membrane arrays, proliferated smooth * Portions of this paper were previously reported (1, 2). t Department of Pathology, University of Wisconsin Medical School, Madison, Wisconsin 53706. endoplasmic reticulum (ER), and altered micro- somal enzyme activity. Materials and Methods Separate groups of male Sprague-Dawley rats initially weighing 100 grams were fed diets containing the following chlorinated a

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