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Vaccination against fowl cholera with acapsularPasteurella multocidaA:1

Authors
Journal
Vaccine
0264-410X
Publisher
Elsevier
Publication Date
Volume
23
Issue
21
Identifiers
DOI: 10.1016/j.vaccine.2004.11.036
Keywords
  • Pasteurella Multocida
  • Fowl Cholera
  • Acapsular Mutant
  • Vaccination

Abstract

Abstract We have previously constructed an acapsular Pasteurella multocida X-73 (serogroup A) mutant strain which was attenuated in virulence for chickens (Chung JY, Wilkie IW, Boyce JD, Townsend KM, Frost AJ, Ghodussi M, Adler B. Role of capsule in the pathogenesis of fowl cholera caused by Pasteurella multocida serogroup A. Infect. Immun. 2001;69:2487–2492). In this study, we have assessed the ability of this acapsular strain (PBA930) to induce protection against wild-type challenge in mice and the natural host chickens. Intramuscular administration of PBA930 to mice stimulated significant protection against X-73 and the heterologous strain P-1059 (A:3), but not against challenge with P-1662 (A:4). No protection was observed when PBA930 was introduced by the intraperitoneal or subcutaneous routes in mice. Significantly, the acapsular strain PBA930 was able to induce protection against challenge with wild type X-73 in chickens.

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