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Liquid membrane phenomena in chlorpromazine action

Authors
Journal
Biophysical Chemistry
0301-4622
Publisher
Elsevier
Publication Date
Volume
17
Issue
3
Identifiers
DOI: 10.1016/0301-4622(83)87003-3
Keywords
  • Chlorpromazine
  • Liquid Membrane
  • Cathecholamine Transport
  • Amino Acid Transport
  • Receptor Orientation
Disciplines
  • Biology

Abstract

Abstract Chlorpromazine has been shown, in the present study, to generate a liquid membrane at an interface in accordance with Kesting's hypothesis [5]. The specific orientation of chlorpromazine molecules in a liquid membrane with hydrophobic ends facing the permeable substances has been found to reduce the permeability of catecholamines and neuroiransmitter amino acids. This observation is discussed in the light of the orientation of receptor proteins in general. The data on transport of catecholamines and neurotransmitter amino acids are discussed in the context of the mechanism of action of chlorpromazine.

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