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Synthesis and cell uptake of a novel dualmodality188Re-HGRGD (D) F-CdTe QDs probe

Authors
Journal
Talanta
0039-9140
Publisher
Elsevier
Publication Date
Volume
85
Issue
2
Identifiers
DOI: 10.1016/j.talanta.2011.04.077
Keywords
  • Quantum Dots
  • 188Re
  • Dualmodality Probe
  • Cell Binding
Disciplines
  • Chemistry

Abstract

Abstract A novel dualmodality probe was prepared by linking 188Re-HGRGD (D) F with CdTe QDs, which was monitored using radio-thin layer chromatography (TLC) and -high performance liquid chromatography (HPLC). The 188Re-HGRGD (D) F-CdTe QDs probe possesses a radiochemistry yield of 92.1% and strong photoluminescence (PL) stability. However, the radiochemical purity of 188Re-HGRGD (D) F-QDs would reduce to 74.8%, which should be further improved, after incubation with newborn calf serum (NCF) for 24 h. Human glioblastoma U87MG cells, known to express a high-affinity to RGD, were used to assess the in vitro cell binding of probe. The results showed that the radio-signal was in accord with the change of PL intensity, which meant the successful integration of 188Re and QDs.

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