Affordable Access

Publisher Website

Synthesis and cell uptake of a novel dualmodality188Re-HGRGD (D) F-CdTe QDs probe

Authors
Journal
Talanta
0039-9140
Publisher
Elsevier
Publication Date
Volume
85
Issue
2
Identifiers
DOI: 10.1016/j.talanta.2011.04.077
Keywords
  • Quantum Dots
  • 188Re
  • Dualmodality Probe
  • Cell Binding
Disciplines
  • Chemistry

Abstract

Abstract A novel dualmodality probe was prepared by linking 188Re-HGRGD (D) F with CdTe QDs, which was monitored using radio-thin layer chromatography (TLC) and -high performance liquid chromatography (HPLC). The 188Re-HGRGD (D) F-CdTe QDs probe possesses a radiochemistry yield of 92.1% and strong photoluminescence (PL) stability. However, the radiochemical purity of 188Re-HGRGD (D) F-QDs would reduce to 74.8%, which should be further improved, after incubation with newborn calf serum (NCF) for 24 h. Human glioblastoma U87MG cells, known to express a high-affinity to RGD, were used to assess the in vitro cell binding of probe. The results showed that the radio-signal was in accord with the change of PL intensity, which meant the successful integration of 188Re and QDs.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments