Man has ever sought knowledge (science), and in different forms. And, empirical knowledge is one of these forms, which is always hoisted as having stood the test of time. Hence, the problem was to see if empirical knowledge has yet overcome the age long problem of fallibilism. The purpose here was to show that empirical knowledge is still fallible. HIV/AIDS as a form of empirical science investigation was used to show case this. This was seen as important because if empirical knowledge has failings these should be shown to be the case. Fallibilism in empirical knowledge was showcased as deriving from politics of experience, foundation of the empirical science, the scourge of imperialism, pseudo-phobia and obsessive solipsism, social and cultural factors in hermeneutics and stereo-typed obsession with final authority. KEY WORDS Science-a body of knowledge systematically acquired or a systematic pursuit of knowledge. Empirical knowledge-knowledge based on the processes of observation, hypothesis, experimentation, theories further verification and laws. HIV- Human Immune Deficiency Virus I and II (HIV I and II) Fallibilism - the plausibility of ever attendant error, known or unknown, implicit or manifest in forms of knowledge, which crave scrutiny and restraint in the conception and application of such.