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How Important is Methicillin-ResistantStaphylococcus aureusas a Cause of Community-Acquired Pneumonia and What is Best Antimicrobial Therapy?

Authors
Journal
Infectious Disease Clinics of North America
0891-5520
Publisher
Elsevier
Volume
27
Issue
1
Identifiers
DOI: 10.1016/j.idc.2012.11.006
Keywords
  • Methicillin Resistance
  • Exotoxins
  • Linezolid
  • Vancomycin
  • Community-Acquired Mrsa
  • Pneumonia
  • Panton-Valentine Leukocidin
  • Staphylococcus Aureus
Disciplines
  • Philosophy

Abstract

The emergence of methicillin-resistant strains of Staphylococcus aureus has raised issues regarding the importance of methicillin-resistant S aureus (MRSA) in community-acquired pneumonia (CAP) and its optimal treatment. Community-acquired MRSA (CA-MRSA) is an important cause of CAP because of the high mortality if not suspected early, and its occurrence in young patients with long life expectancy. Certain clinical features can increase the probability of CA-MRSA as a cause of CAP. The consistent trend toward better outcomes for documented MRSA pneumonia suggests that linezolid be considered the drug of choice for documented MRSA CAP, especially for CA-MRSA.

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