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Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinicopathological and biological factors in invasive breast cancer

Authors
Journal
BMC Cancer
1471-2407
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Disciplines
  • Biology
  • Medicine

Abstract

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer RESEARCH ARTICLE Open Access Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico- pathological and biological factors in invasive breast cancer Oscar Fernández-Guinea1,2, Alejandro Andicoechea1,3, Luis O González1,4,5, Salomé González-Reyes1,5, Antonio M Merino6, Luis C Hernández7, Alfonso López-Muñiz7, Paz García-Pravia2, Francisco J Vizoso1,3,5* Abstract Background: To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors. Methods: Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2. Results: Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (≤ 150%) of maximum enhancement before two minutes than among those ones showing a high percentage (>150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042). Conclusions: Variations i

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