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Does the complex of aminoacyl-tRNA synthetases and tRNA-modifying enzymes prevent miscoding?

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
178
Issue
1
Identifiers
DOI: 10.1016/0014-5793(84)81228-4
Keywords
  • Aminoacyl-Trna Synthetase
  • Multienzyme Complex
  • Trna Modification
  • Wobble Position
  • Miscoding
Disciplines
  • Biology

Abstract

Abstract Several aminoacyl-tRNA synthetases of higher eukaryotes have always been found as multienzyme complexes. There are indications that these complexes can be associated with some tRNA-modifying enzymes. The function of such complexes is unclear. I have noticed that 6 out of 7 aminoacyl-tRNA synthetases most commonly occurring in complexes correspond to a group of tRNAs which must always contain a modified U in the first position of their anticodons. A hypothesis is proposed according to which association of 6 aminoacyl-tRNA synthetases with U-modifying enzymes can protect a cell from miscoding.

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